Retinoids for ichthyosis

View our collaboration clinic with Ichthyosis Support Group. ISG skin experts were here to answer all of your questions about self-management, treatments and beyond!
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hsummers81@gmail.com
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by hsummers81@gmail.com on Thu May 12, 2022 10:15 am

Retinoids for ichthyosis

Why is the use of retinoids to treat Ichthyosis so controversial? Dermatologists recommend it for the severe types, but so many people in the support groups feel strongly against their use. Can you reassure the community of their safety somehow, and explain why dermatologists are keen to use them please? With specific reference to paediatrics please

Dr Gabriela Petrof
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by Dr Gabriela Petrof on Thu May 12, 2022 5:47 pm

Re: Retinoids for ichthyosis

Retinoids are commonly used by Dermatologists for a range of skin conditions. The truth is we don't know much about long-term use of oral retinoids. There is no consensus among Dermatologist about monitoring but clinical experience suggest they are safe.
The main concerns are teratogenicity if the person becomes pregnant while taking them and also- the need to avoid getting pregnant for 3 years after STOPPING the drug. In young children it can have an impact of bone growth and development. It can commonly lower the white cell counts and cause elevated liver tests.
Every case should be assessed individually and the risks and benefits discussed. Although safe and a good treatment option, starting retinoids needs careful consideration and monitoring.

Edel O' Toole
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by Edel O' Toole on Fri May 13, 2022 7:47 pm

Re: Retinoids for ichthyosis

I have prescribed acitretin for many patients with ichthyosis and other conditions.

Side effects occur more often with high doses of retinoids. I always therefore prescribe the lowest dose that has some effect and find that this is a safe approach along with routine blood monitoring.

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